BLEND, PORTRAYAL AND NATURAL ASSESSMENT OF SOME EPIC PYRIDINE CONTAINING AZETIDINONE SUBORDINATES

  • Sankara Malathi Department of pharmaceutical chemistry,KR College of Pharmacy, Bangalore, India.
    sankaramalathi94@gmail.com
  • C. Nagendra Prasad Department of Pharmaceutical Chemistry, Annamacharya college of Pharmacy, JNTUA, kadapa, Andhra Pradesh.
  • Sidde. Lahari Department of Pharmaceutical Chemistry, Balaji college of Pharmacy, JNTUA, Anantapur, Andhra Pradesh, 515001.

Abstract

Six epic Pyridine containing azetidinone subordinates (Azetidinone II A-F) have been blended from Schiff base by treating 2-aminopyridine with substituted sweet-smelling aldehydes each were taken equimolar fixation within the sight of frigid acidic corrosive as an impetus utilizing Grindstone method. Further Schiff base include triethanol amine, chloroacetyl chloride and 1, 4-dioxane experiences buildup pursued by end response result into novel pyridine containing azetidinone subsidiaries. The recently integrated subordinates were described by utilizing spectroscopic techniques (IR, 1H-NMR, MASS) and screened for chosen rheumatoid joint pain.Every one of the subordinates were screened for rheumatoid joint inflammation action by in-vitro examines (protein denaturation measure) utilizing Indomethacin as a standard. The consequences of rheumatoid joint pain action have show increasingly strong movement is compound II C when contrast with standard and shows less intense action is compound II A.

Keywords: Azetidinone, Pyridine, Rheumatoid arthritis, Schiff base

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Sankara, M., N. P. C, and L. Sidde. “BLEND, PORTRAYAL AND NATURAL ASSESSMENT OF SOME EPIC PYRIDINE CONTAINING AZETIDINONE SUBORDINATES”. International Journal of Pharmacognosy and Chemistry, June 2020, pp. 12-18, https://www.saapbooks.com/journals/index.php/ijpc/article/view/16.
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