• Sankara Malathi Department of pharmaceutical chemistry,KR College of Pharmacy, Bangalore, India.
  • C. Nagendra Prasad Department of Pharmaceutical Chemistry, Annamacharya college of Pharmacy, JNTUA, kadapa, Andhra Pradesh.
  • Sidde. Lahari Department of Pharmaceutical Chemistry, Balaji college of Pharmacy, JNTUA, Anantapur, Andhra Pradesh, 515001.


Six epic Pyridine containing azetidinone subordinates (Azetidinone II A-F) have been blended from Schiff base by treating 2-aminopyridine with substituted sweet-smelling aldehydes each were taken equimolar fixation within the sight of frigid acidic corrosive as an impetus utilizing Grindstone method. Further Schiff base include triethanol amine, chloroacetyl chloride and 1, 4-dioxane experiences buildup pursued by end response result into novel pyridine containing azetidinone subsidiaries. The recently integrated subordinates were described by utilizing spectroscopic techniques (IR, 1H-NMR, MASS) and screened for chosen rheumatoid joint pain.Every one of the subordinates were screened for rheumatoid joint inflammation action by in-vitro examines (protein denaturation measure) utilizing Indomethacin as a standard. The consequences of rheumatoid joint pain action have show increasingly strong movement is compound II C when contrast with standard and shows less intense action is compound II A.

Keywords: Azetidinone, Pyridine, Rheumatoid arthritis, Schiff base


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How to Cite
Sankara, M., N. P. C, and L. Sidde. “BLEND, PORTRAYAL AND NATURAL ASSESSMENT OF SOME EPIC PYRIDINE CONTAINING AZETIDINONE SUBORDINATES”. International Journal of Pharmacognosy and Chemistry, June 2020, pp. 12-18,
Research Article